MSDS No. NPDS0126
Material Safety Data Sheet
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MATERIAL IDENTIFICATION
(UBIDECARENONE) COENZYME Q10
MSDS NUMBER: NPDS0126
Revision Date: June 2, 2003
GRADE: (Bulk Pharmaceutical Chemical) Healthy Food
TRADE NAME: UBIDECARENONE
CHEMICAL NAME:2-(3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-
tetracontadecaenyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone
SYNONYMS: COENZYME Q10, CoQ10, UBIQUINONE-10
CHEMICAL STRUCTURE
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COMPONENTS: UBIDECARENONE 100%
Material: UBIDECARENONE
CAS NUMBER 303-98-0
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PHYSICAL DATA
Mellting Point: about 48 degrees centigrade
Solubility: Soluble in ether, very slightly soluble in dehydraated ethanol, and
practically insoluble in water.
Form: Crystalline powder
Color: Yellow to Orange
HAZARDOUS REACTIVITY
Stability: Stable at normal temperatures and storage conditions.
It gradually decomposes by light, and its color becomes deep.It produces
ubicromenol by mixing with alkaline/basic material.
It decomposes by heating over 120 degrees centigrade.
Incompatibility: Incompatible with alkaline/basic material.
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FIRE DATA
FIRE HAZARDS
Hazardous gases/vapors produced in fire are CO and CO2.
EXTINGUISHING MEDIA
Water spray. Foam, Dry chemical, CO2
SPECIAL FIRE FIGHTING INSTRUCTIONS
Evacuate personnjel to a safe area. Keep personnel removed and upwind of fire.
Wear self-contained breathing apparatus. Wear full protective equipment.
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HEALTH HAZARD INFORMATION
REPRODUCTIVE EFFECTS DATA
Fetotoxicity (except death); Developmental abnormalities; Musculoskeletal system;
Physical oral rat TDLO 42mg/kg 9-15D preg
Post-implantation mortality; Fetal death; Other developmental abnormalities oral rat
TDLO 4200mg/kg 9-15D preg
Developmental Abnormalities; Musculoskeletal system;
Physical oral mouse TDLO 42mg/kg 7-13D preg
TOXICITY EFFECTS DATA
Altered sleep time; Somnolence (general depressed activity) oral rat LD50>4,000mg/kg
Altered sleep time; Somnolence (general depressed activity) Subcutaneous rat LD50>500mg/kg
Altered sleep time; Somnolence (general depressed activity) oral mouse LD50>4,000mg/kg
Altered sleep time; Somnolence (general depressed activity) Subcutaneous mouse LD50>500mg/kg
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SAFETY PRECAUTIONS
Do not breathe dust. Avoid contact with eyes, skin or clothing.
Wash thoroughly after handling. Wash clothing after use.
FIRST AID
SKIN CONTACT
In case of contact, wash skin with soap and water.
Call a physician. Wash contaminated clothing before reuse.
EYE CONTACT
In case of contact, immediately flush eyes with plenty of water for at least
15 minutes. Call a physician.
INGESTION
If ingested, wash mouth with water sufficiently.
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PROTECTION INFORMATION
GENERALLY APPLICABLE CONTROL MEASURES AND PRECAUTIONS
Use only with adequate ventilation. Keep container in a cool, dry and dark place.
Keep container tightly closed. Avoid dust generation.
Close container after each use. Do not consume food, drink or tobacco in the areas
where they may become contaminated with this material.
PERSONAL PROTECTIVE EQUIPMENT
EYE/FACE PROTECTION
Wear safety glasses. Wear full face protection when judged that the possibility exists for
eye and face contact due to dust generation or spraying/splashing of solutions.
RESPIRATORS
This material does not have established exposure limits. Wear an appropriate NIOSH/MSHA
approved air purifying respirator or positive pressure air-supplied respirator in situation
where a respirator is judged appropriate to prevent inhalation of dust.
PROTECTIVE CLOTHING
Wear rubber gloves.
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DISPOSAL INFORMATION
SPILL, LEAK, OR RELEASEE
NOTE: Review FIRE HAZARDS and SAFETY PRECAUTIONS before proceeding with clean up.
Use appropriate PERSONAL PROTECTIVE EQUIPMENT during clean up. Evacuate personnel,
thoroughly ventilate areas, use self-contained breathing apparatus.
Shovel or sweep up. Avoid generating dust. Ventilate area and wash spill site
after material pickup is complete.
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WASTE DISPOSAL
Treatment, storage, transportattion and disposal must be in accordance with
applicable regulations. Incinerate material in accordance with applicable regulations.
STORAGE CONDITIONS
Store in well ventilated area. Store in a cool and dark place. Keep container tightly closed.
Do not store or consume food, drink or tobacco in areas where they may become
contaminated with this material. Store in a dry area. Avoid dusting conditions.
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30mg of Ubidecarenone (CoQ10) is the maximum recommended daily dose in Japan.
References:
1) I. Imada, Y. Sanno and H. Morimoto; Chem. Pharm. Bull, 12, 1042 (1964)
2) I. Imada and H. Morimoto; Chem. Pharm. Bull, 12, 1047 (1964)
3) I. Imada and H. Morimoto; Chem. Pharm. Bull, 12, 1051 (1964)
4) I. Imada, Y. Sanno and H. Morimoto; Chem. Pharm. Bull, 12, 1056 (1964)
5) H. Morimoto, I.Imade and G.Goto; Liebigs Ann. Chem., 735, 65 (1970)
6) Y. Notake, S. Tamura, S. Toyoshima, H. Fujita, Y. Suzuki and T. Chiba; Iyakuhin Kenkyu 3,306 (1972)
7) T. Chiba, T. Watanabe, Y. Kume, K. Sugiyama and H. Shiojiri; Oyo Yakuri 6,769 (1972)
The data in this Material Safety Data Sheet relates only the specific material designated
herein and does not relate to use in combination with any other material or in any process.
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