The Science Behind
(Shiitake Lentinus edodes Mycelial Culture Extract)
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The Science Behind
(Shiitake Lentinus edodes Mycelial Culture Extract)
Research • Patents • Manufacturing Excellence
Technical Brief
A concise overview of the scientific foundation, manufacturing expertise, patents and published research behind LEM®.
Patent Portfolio Overview
An overview of the patented technologies that have supported the development and evolution of LEM® over decades.
Decades of Research
LEM® has been developed through decades of scientific research and continuous technological innovation in Japan.
Its scientific foundation is demonstrated by extensive published research covering immunology, nutritional science and other biological research fields.
This long-standing commitment to research continues to reinforce the quality, reliability and scientific credibility of LEM®.
Patent Portfolio
LEM® is protected by multiple Japanese patents covering proprietary manufacturing technology, extraction methods and functional applications.
These patented technologies have contributed to the unique characteristics and consistent quality of LEM® for many years.
Scientific Publications
LEM® has been the subject of numerous published scientific studies over several decades.
Research has explored immune function, antiviral activity, liver health, neuroprotection and other biological functions.
These publications provide a strong scientific basis for the continued evaluation of LEM®.
Manufacturing Process
LEM® is manufactured using a proprietary solid-state cultivation process based on sugarcane bagasse and rice bran, followed by hot-water extraction, filtration, concentration and drying.
This carefully controlled manufacturing process ensures the consistency, quality and reproducibility of the final ingredient.
Quality Standards
LEM® is manufactured under established quality management systems at the GMP and FSSC22000 certified production facilities in Japan.
Every production lot undergoes strict quality control procedures to maintain consistent quality for professional distribution channels.
Each production lot is fully traceable through the printed best-before date and lot code on every product package.
Together, research, patented technologies and proprietary manufacturing
form the scientific foundation of LEM®.
YBS Corporation | Tokyo, Japan | Since 1981
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