AGARICUS BLAZEI MURILL EXTRACT
Concentrated Liquid & Powder - Soft Capsule - Granule - Tablet

Activates Human Immune System




Agaricus originates from Piedade in the suburbs of Sao Paulo, Brazil. About 3 decades ago, one American researcher got aware of the fact that the inhabitants in this area were rarely inflicted by adult diseases and they eat Agaricus on daily diet. It was called "Cogmelo de Deus" locally which means "God's mushroom".
It was the same time that Agaricus was firstly brought into Japan by Dr. Shoji Shibata, a professor in the Pharmacological Dept of Tokyo University. Another professor named Dr. Tetsuo Ikegawa of the National Cancer Center jointly worked with Dr. Shibata on the pharmacological effects of Agaricus. The research findings were announced at the General Convention of the Japan Pharmacological Association and the Japan Cancer Association. Their experiments utilizing mice showed that the polysaccharide beta-glucan contained in Agaricus significantly activated the immune system.




GASTRONOMIC EFFECTS
Agaricus Blazei Murill strengthens the immune function of inhibition for carcinomatous growth and activates natural killer cells. Among other components in Agaricus, the known anti-tumor agents are Beta-glucan and other polysaccharides which are highly concentrated in the liquid/powdered extract of Agaricus.

Polysaccharide contained in Agaricus Blazei Murill vitalizes generation of interferon and interleukin in guinea pigs. This effect indirectly functions to hold down proliferation of cancer cells. Also, it prevents viruses and other external matters from invading the tissue.

Clinical findings obtained jointly with universtity and hospital researchers were announced at the General Convention of the Japan Cancer Association in 1980. They showed that polysaccharide of Agaricus Blazei Murill is effective against Ehrlich's ascites carcinoma sigmoid coloniccancer, ovarian cancer, breast cancer, lung cancer and liver cancer as well as against solid cancer.

The findings also show that it activates metabolism by revitalizing normal biological tissue. Digestive enzymes such as amylase trypsin martase and the protease contained in fungus also enhances digestion. Besides, tyrosinase which oxydizes tyrosine and produces melanin, has a hypotensive effect. Furthermore, melanin protein that is effective in the generation of semen, hair and egg white was just recently discovered in Agaricus Blazei Murill.

Its physiological effects are anti-tumor, anti-allergic action and reduction of blood sugar level.


SPECIFICATIONS for Double-Concentrated** Agaricus Extract Liquid
(**1kg of Agaricus extract liquid processed and obtained from 2kg dry Agaricus)
Moisture not more than 30% Atmospheric pressure heating & drying
Heavy Metals (as Pb). not more than 50 ppm Sodium sulfide colorimetric method
Arsenic (as AS2O3) not more than 2 ppm DDTC-Ag absorption photometry
Aerobic Plate Count not more than 3000/g Agar plate culture method
Coliform Organisms negative BGLB method
Beta-glucan more than 2% Enzyme gravimetric method



Certificate of Analysis No.201120756-001 dated 12/25/2001 for
Double-Concentrated Agaricus Extract Liquid (Issued by Japan Food Research Laboratories)
Moisture 27.4% Atmospheric pressure heating & drying
Protein (N x 6.25) 29.3% Kjeldahl method (1)
Fat 0.7% Acid digestion
Ash 9% Direct ashing method
Non-fibrous carabohydrate 33.6% (2)
Energy 258kcal/100g (3)
Sodium 52.2mg/100g Atomic absorption photometry
Beta-glucan 2.1g/100g Enzyme gravimetric method
(1)nitrogen-protein conversion factor: 6.25
(2)Formula on Nutrition Labelling Standard: 100-(moisture+protein+fat+ash+dietary fiber)
(3)Energy conversion factor on Nutrition Labelling Standard: protein 4; fat 9; carbohydrate-(maltitol+raffinose) 4; maltitol 2; raffinose 2.
Note: Nutrition Labelling Standard in the Announcement No. 146 given by Health and Welfare Ministry in 1996
Process of Manufacture for Double-concentrated Agaricus Extract Liquid:
Hot-water extraction Λ Centrifugation (separation of transudate from solid)Λ 2nd Hot-water extraction of solid Λ Centrifugation (separation of transudate from solid) Λ Diatomite filtration of transudate Λ Extracted liquid Λ Vacuum concentration Λ Concentrated extracted liquid Λ Sterilization by heating (30 minutes, 95Ž)@ΛFilling




SPECIFICATIONS for Powdered Agaricus Extract
Description
Brown or dark brown powder
 Visual inspection
Moisture
not more than 8.5%
 Atmospheric pressure heating & drying
Particle size not more than 100 sieve mesh Sieving method
Heavy Metals (as Pb)
not more than 20 ppm
 Sodium sulfide colorimetric method
Arsenic (As2O3) not more than 2 ppm DDTC-Ag absorption photometry
Aerobic Plate Count
not more than 3000/g
 Agar plate culture method
Coliform Organisms
negative
 BGLB method
Protein (Nx6.25)
15.1%
 Kjeldahl method (1)
Fat
0.1%
 Acid digestion
Ash
5.1%
 Direct ashing method
Non-fibrous carbohydrate
73.8%
 (2)
(1)nitrogen-protein conversion factor: 6.25
(2)Formula on Nutrition Labelling Standard: 100-(moisture+protein+fat+ash+dietary fiber)
Note: Nutrition Labelling Standard in the Announcement No. 146 given by Health and Welfare Ministry in 1996

Certificate of Analysis No.204031832-001dated April 7, 2004 for Powdered Agaricus Extract
(Issued by Japan Food Research Laboratories)
Lot No.040319
Moisture 4.7g/100g Atmospheric pressure heating & drying
Protein 18.7g/100g Kjeldahl method (1)
Fat not more than 0.1g/100g Acid digestion
Ash 6.5g/100g Direct ashing method
Non-fibrous carbohydrate 70.1g/100g (2)
Energy 355kcal/100g (3)
Sodium 39.9mg/100g Atomic absorption photometry
Beta-glucan 1.3g/100g Enzyme gravimetric method
(1)nitrogen-protein conversion factor: 6.25
(2)Formula on Nutrition Labelling Standard: 100-(moisture+protein+fat+ash+dietary fiber)
(3)Energy conversion factor on Nutrition Labelling Standard: protein 4; fat 9; carbohydrate-(maltitol+raffinose) 4; maltitol 2; raffinose 2.
Note: Nutrition Labelling Standard in the Announcement No. 176 given by Health, Labour and Welfare Ministry in 2003

Certificate of Analysis No.204031832-002 dated April 7, 2004 for Powdered Agaricus Extract
(Issued by Japan Food Research Laboratories)
Lot No.040319
Heavy metals (as Pb) 5.9 ppm Sodium sulfide colorimetric method
Aerobic plate count 2.7 x 103/g Agar plate culture method
Coliform bacteria Negative/2.22g BGLB Method


Process of Manufacture for Powdered Agaricus Extract:
Crushed agaricus mushroom Λ Purified water Λ@Hot-water extraction (2 hours stirring, 85Ž) Λ Cooling (50Žj Λ Centrifugation (separation of transudate from solid) Λ Suction filtration Λ Extracted liquid Λ Vacuum concentration Λ Concentrated extracted liquid Λ Spray drying Λ Filling




FORMULATION/DOSAGE:

Concentrated Extract liquid and powder, soft capsule, retort-packed extract liquid, granular sticks and tablet
Recommended daily dosage is 5g to 8g as counted in weight of dry agaricus.




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